Plato’s Timaeus inspired a uniquely enduring interest across disciplines. In the centuries between its composition and the seventeenth century, scholars looked to this dialogue for answers to questions about the structure of the universe and how to live a healthy and happy life. They saw cosmology as vital to medicine and ethics; and, for them, harmony in music and architecture facilitated balance in the human soul. This interdisciplinary collection explores how the dialogue transformed the disciplines of cosmology, music, medicine, and architecture, and how new intellectual and cultural developments in turn shaped and re-contextualized interpretations of Plato’s ideas.