Describes the statistical principles of good experimental design, explaining that good design of experiments is crucial to the success of research. Emphasizing the logical principles of statistical design, Professor Mead employs a minimum of mathematics. Throughout he assumes that the large-scale analysis of data will be performed by computers and he thus devotes more attention to discussions of how all of the available information can be used to extract the clearest answers to many questions. The principles are illustrated with a wide range of examples drawn from medicine, agriculture, industry, and other disciplines. Numerous exercises are given to help the reader practice techniques and to appreciate the difference that good design of experiments can make to a scientific project.