This book constitutes the refereed proceedings of the 17th International Conference on Similarity Search and Applications, SISAP 2024, held in Providence, RI, USA, during November 4-6, 2024. The 13 full papers, 7 short papers and 4 Indexing Challenge papers included in this book were carefully reviewed and selected from 32 submissions. They focus on efficient similarity search methods addressing the challenges of exploring similar items and managing vast machine-learning data sets efficiently.