This book offers a comprehensive analysis of the significant intersection where human factors and cyber-physical system (CPS) reliability meet. Physical component integration has become essential in a number of industries, including smart infrastructure, health care, transportation, and manufacturing. However, human performance and decision-making inside these complex frameworks also play an important part in determining the reliability of CPS. Key subjects discussed include the role of human factors in CPS reliability, machine learning and deep learning applications in cybersecurity, resilience engineering, cognitive task management, efficient team collaboration and communication, error control, and cybersecurity awareness. The book will be read by professionals and scholars working in engineering, human factors, reliability engineering, cybersecurity, and related topics. In order to obtain a greater knowledge of the crucial role that human factors play in providing the reliability and trustworthiness of CPS, it is also beneficial for students pursuing courses or research in CPS, human&computer interface (HCI), and systems engineering.