This book constitutes the refereed proceedings of the 15th International Conference on the Quality of Information and Communications Technology, QUATIC 2022, held in Talavera de la Reina, Spain, in September 2022. The 18 full papers and 3 short papers were carefully reviewed and selected from 54 submissions. The papers are organized in topical sections: smart and advanced systems; verification and validation; skills and education; industrial experiences and applications; safety, security and privacy.