The two volume set LNCS 15937 + 15938 constitutes the proceedings of the 12th Iberian Conference on Pattern Recognition and Image Analysis, IbPRIA 2025, which took place in Coimbra, Portugal, during June 30&July 3, 2025. The 67 full papers included in the proceedings were carefully reviewed and selected from 115 submissions. They were organized in topical sections as follows: Part I: Computer vision; faces, body, fingerprints and biometrics; machine and deep learning; explainability, bias and fairness in DL; Part II: Natural language processing; biomedical applications; and other applications.