This book constitutes the proceedings of the 22nd International Conference on Parallel and Distributed Computing, Applications, and Technologies, PDCAT 2021, which took place in Guangzhou, China, during December 17-19, 2021.The 24 full papers and 34 short papers included in this volume were carefully reviewed and selected from 97 submissions. The papers are categorized into the following topical sub-headings: networking and architectures, software systems and technologies, algorithms and applications, and security and privacy.