The social and environmental challenges we face today are complex and interdependent. Leaders and experts worldwide acknowledge that we cannot address them in isolation and that to keep doing so is to intensify the problem. This book connects the dots between a group of diverse, but overlapping, professional domains: design, mission-oriented innovation, foresight and futures design, system innovation and leadership. The authors mix methodology and theory with real-life case studies and compelling visual models to aid readers in navigating a new story, balancing tensions in time scale and mindset, learning through experiments and working collaboratively. Aimed at policy makers, practitioners and educators, this book encourages a new and heightened awareness of systemic change that can lead to societal transformation in support of a sustainable future.