This book presents innovative breakthroughs in operational excellence that can solve the operational issues of smart factories. It illustrates various tools and techniques of Lean Six Sigma 4.0 and details their suitability for manufacturing and service systems. Lean Six Sigma 4.0 for Operational Excellence Under the Industry 4.0 Transformation provides technological advancement in operational excellence and offers a framework to integrate Lean Six Sigma and Industry 4.0. The book is a guide to dealing with new operational challenges and explains how to use Industrial IoT, Sensors, and AI to collect real-time data on the shop floor. While focusing on developing a toolset for Lean Six Sigma 4.0, this book also presents the enabling factors to adopt Lean Six Sigma 4.0 in the manufacturing and service sectors. The book will help industrial managers, practitioners, and researchers on the path of process improvement in modern-day industries.