This is a documented narration of dramas played out from 1578 to 2000 in the Cape Horn area, Tierra del Fuego, by the native Yamana and Charles Darwin, explorers, sealers, whalers, Anglican missionaries, and three other famous people who made contact with some of the last Yamana. The narration, based on geographical, historical, and ethnographic sources and Anne Chapman’s fieldwork with the last few descendants of the Yamana, describes the Europeans’ motives for going to Tierra del Fuego and the Yamana’s motives for staying there some 6,000 years, what the outsiders gained, and what the Yamana lost. The main objective of this work is to incorporate the hunting-gathering Yamana into world history by evoking their way of life, especially Jemmy Button and Fuegia Basket in comparison with the outsiders they encountered, especially Drake, Cook, and Darwin in their scientific world in the context of their experiences with the Yamana in Tierra del Fuego and nearby areas.