This book presents the best papers from the International Conference on Data Science for Computational Security (IDSCS 2025), hosted by CHRIST (Deemed to be University), India, and technically sponsored by The Tejas Scientific Researcher Foundation, India, held on November 14&15, 2025. This book covers current research in data science, data security, data analytics, artificial intelligence, machine learning, computer vision, algorithm design, computer networking, data mining, big data, text mining, knowledge representation, soft computing, and cloud computing.