This book provides a coherent framework for understanding the essence of complex systems and the nature of digital transformations, analyzes challenges of and patterns in innovative development, and shares a wealth of insights and best practices, resulting in the most extensive coverage of the topic available. In particular, the book's cutting-edge contributions, prepared by scientists, engineers, and field experts,focus on the design, implementation, and evaluation of practical interventions that promote the innovative and sustainable development of complex systems. In addition to sharing a rich collection of cases from around the world, they provide a broad interdisciplinary analysis of collaboration mechanisms, theories and approaches to support and accelerate the development of complex systems.