This book provides a comprehensive and accessible exploration of how Artificial Intelligence (AI) is transforming the field of Genomics and personalized medicine. The book brings together the latest methods, tools, and real-world applications that enable scientists and clinicians to interpret complex genetic data, discover disease-causing patterns, and design precision therapies. Covering topics from deep learning and multi-omics integration to ethical and regulatory considerations, the book bridges the gap between computational innovation and clinical translation. Designed for researchers, students, healthcare professionals, and biotech innovators, this book offers clear explanations, illustrative case studies, and forward-looking insights into how AI is shaping the future of medicine and human health.