This 2-volume set CCIS 2387 + 2388 constitutes the proceedings of the Second International Conference on Applied Intelligence, ICAI 2024, held in Zhengzhou, China, during November 22-25, 2024. The 72 full papers presented in this proceedings were carefully reviewed and selected from 228 submissions. The papers cover a wide range on theoretical aspects of biomedical data modeling and mining; computer vision; and deep learning. They were organized in topical sections as follows: Part I: Biomedical data modeling and mining; information security; pattern recognition;  Part II: Image Processing; intelligent data analysis and prediction; machine learning;