This book constitutes the refereed proceedings of the 22nd International Conference on Analytical and Stochastic Modelling Techniques and Applications, ASMTA 2015, held in Albena, Bulgaria, in May 2015. The 15 full papers presented in this book were carefully reviewed and selected from numerous submissions. The papers discuss the latest developments in analytical, numerical and simulation algorithms for stochastic systems, including Markov processes, queueing networks, stochastic Petri nets, process algebras, game theory, etc.