This book comprises high-quality refereed research papers presented at the Fourth International Conference on Computer Science, Engineering and Education Applications (ICCSEEA2021), held in Kyiv, Ukraine, on January 23-24, 2021, organized jointly by the National Technical University of Ukraine "Igor Sikorsky Kyiv Polytechnic Institute", National Aviation University, and the International Research Association of Modern Education and Computer Science. The topics discussed in the book include state-of-the-art papers in computer science, artificial intelligence, engineering techniques, genetic coding systems, deep learning with its medical applications, and knowledge representation with its applications in education. It is an excellent source of references for researchers, graduate students, engineers, management practitioners, and undergraduate students interested in computer science and their applications in engineering and education.